6-Chloro-2-(trifluoromethyl)nicotinic acid

Name: 6-Chloro-2-(trifluoromethyl)nicotinic acid
Brand: ChemScene
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CAS No. 261635-83-0
Cat. No. CS-W000652
Purity≥98%
MDL No.MFCD11840271

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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6-Chloro-2-(trifluoromethyl)nicotinic acid|CS-W000652

Structure of 261635-83-0

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Description

6-Chloro-2-(trifluoromethyl)nicotinic acid features a trifluoromethyl group at the 2-position and a chlorine substituent at the 6-position of the nicotinic acid scaffold. This electron-deficient heterocycle serves as a key building block in medicinal chemistry, particularly for developing kinase inhibitors and bioactive compounds requiring enhanced metabolic stability and lipophilic character.

Application

6-Chloro-2-(trifluoromethyl)nicotinic acid serves as a versatile building block in medicinal chemistry, enabling the synthesis of biologically active heterocycles and pharmaceutical intermediates. Its electron-deficient pyridine core facilitates nucleophilic aromatic substitution and palladium-catalyzed coupling reactions. The trifluoromethyl group enhances metabolic stability and membrane permeability, while the chloro substituent provides a reliable handle for further functionalization. This compound exhibits excellent bench stability and compatibility with standard purification methods, making it ideal for scalable synthesis workflows.

General Information

CAS No. 261635-83-0
Cat. No. CS-W000652
Purity ≥98%
MDL No. MFCD11840271
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₇H₃ClF₃NO₂
Molecular Weight None
Synonym(s) 6-chloro-2-(trifluoromethyl)pyridine-3-carboxylic acid
SMILES ClC1=NC(C(F)(F)F)=C(C(O)=O)C=C1

Computational Chemistry Data

TPSA 50.19
LogP 2.452
H_Acceptors 2
H_Donors 1
Rotatable_Bonds 1

Safety Information

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GHS Pictogram : N/A	GHS No : N/A
Signal Word : N/A	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : N/A
Precautionary Statements : N/A

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Other Classifications

Building Blocks Functional Group Chloride

Building Blocks Functional Group Carboxylic Acid

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

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6-Chloro-2-(trifluoromethyl)nicotinic acid

CAS No. 261635-83-0

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