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Structure of 261635-93-2
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2-Methyl-6-(trifluoromethyl)nicotinic acid features a sterically hindered trifluoromethyl group at the pyridine ring's para position, enhancing electron-withdrawing character and metabolic stability. This structural motif enables efficient integration into bioactive scaffolds, particularly in kinase inhibitors and medicinal chemistry libraries. The carboxylic acid functionality supports direct derivatization or salt formation for improved solubility and handling under standard conditions.
2-Methyl-6-(trifluoromethyl)nicotinic acid serves as a versatile building block in medicinal chemistry, enabling the synthesis of bioactive heterocycles and pharmaceutical intermediates. Its electron-deficient pyridine core and orthogonal functional groups facilitate diverse transformations, including amidation, esterification, and Suzuki coupling. The trifluoromethyl group enhances metabolic stability and lipophilicity, while the methyl substituent provides a handle for further derivatization. This compound exhibits good bench stability and is amenable to standard purification methods, making it well-suited for scalable synthesis workflows.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
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Lot numbers can be found on the outside label of a product: