Lot numbers can be found on the outside label of a product:
(3-Bromo-2-fluorophenyl)methanol
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CAS No. 261723-32-4
- Cat. No. CS-W021084
- Purity≥98%
- MDL No.MFCD09842441
*For research and further manufacturing use only, not for direct human use.
Structure of 261723-32-4
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General Information
- CAS No. 261723-32-4
- Cat. No. CS-W021084
- Purity ≥98%
- MDL No. MFCD09842441
- Storage Store at room temperature
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₇H₆BrFO
- Molecular Weight 205.02
- Synonym(s) 1-Bromo-2-fluoro-3-(hydroxymethyl)benzene
- SMILES OCC1=CC=CC(Br)=C1F
Description
(3-Bromo-2-fluorophenyl)methanol features a strategically positioned bromine and fluorine substituent on the aromatic ring, enabling selective functionalization in cross-coupling reactions. The benzylic alcohol moiety offers a reactive handle for derivatization, while the molecule exhibits excellent stability under standard handling conditions.
Application
(3-Bromo-2-fluorophenyl)methanol serves as a versatile building block in medicinal chemistry, enabling direct introduction of a brominated aryl alcohol motif. Its stability under standard handling conditions and compatibility with palladium-catalyzed cross-coupling reactions facilitate efficient C–C bond formation. The ortho-fluoro and meta-bromo substituents provide orthogonal reactivity for downstream functionalization, supporting modular synthesis of complex heterocyclic scaffolds and pharmaceutical intermediates.
Synthesis
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Route1
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In-stock
161957-56-8 - ~83%
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In-stock
261723-32-4
References
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Crosignani, Stefano; Pretre, Adeline; Jorand-Lebrun, Catherine; Fraboulet, Gaele; Seenisamy, Jeyaprakashnarayanan; Augustine, John Kallikat; Missotten, Marc; Humbert, Yves; Cleva, Christophe; Abla, Nada; Daff, Hamina; Schott, Olivier; Schneider, Manfred; Burgat-Charvillon, Fabienne; Rivron, Delphine; Hamernig, Ingrid; Arrighi, Jean-Francois; Gaudet, Marilene; Zimmerli, Simone C.; Juillard, Pierre; Johnson, Zoe Journal of Medicinal Chemistry, 2011 , vol. 54, # 20 p. 7299 - 7317
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Route2
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In-stock
149947-15-9 - ~%
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In-stock
261723-32-4
References
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sanofi-aventis Patent: US2011/65699 A1, 2011 ; Location in patent: Page/Page column 11 ;
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Route3
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In-stock
1072-85-1 - ~%
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In-stock
261723-32-4
References
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Pirrung, Michael C.; Park, Kaapjoo Bioorganic and Medicinal Chemistry Letters, 2000 , vol. 10, # 18 p. 2115 - 2118
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Safety Information
Download SDS|
GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Quality Control
Computational Chemistry Data
- TPSA 20.23
- LogP 2.0805
- H_Acceptors 1
- H_Donors 1
- Rotatable_Bonds 1
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Key Words
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