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Structure of 261951-80-8
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3-Fluoro-2-trifluoromethylbenzoic acid features a strategically positioned trifluoromethyl group and fluorine substituent that enhance electron-withdrawal and metabolic stability. This combination imparts high lipophilicity and targeted electronic effects, making it valuable for medicinal chemistry applications requiring precise modulation of acidity and binding affinity in bioactive scaffolds.
3-Fluoro-2-trifluoromethylbenzoic acid serves as a valuable building block in medicinal chemistry, enabling the synthesis of fluorinated aromatic scaffolds with enhanced metabolic stability and membrane permeability. Its ortho-fluoro and trifluoromethyl groups provide complementary electronic effects and steric bulk, facilitating diverse functionalization and coupling reactions. The carboxylic acid functionality enables straightforward derivatization into amides, esters, or acyl chlorides, supporting modular synthesis workflows. Bench-stable and readily purified by recrystallization, it functions effectively in standard cross-coupling and heterocycle-forming processes.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H315-H319-H335
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Precautionary Statements : P233-P260-P261-P264-P271-P280-P302+P352-P304+P340-P362-P405-P501
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Lot numbers can be found on the outside label of a product: