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Structure of 26218-78-0
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Methyl 6-bromonicotinate features a brominated pyridine ring that enables direct functionalization in cross-coupling reactions. The ester group provides a handle for further derivatization, while the electron-deficient aromatic core enhances reactivity in transition-metal-catalyzed processes. This compound serves as a key intermediate in the synthesis of bioactive heterocycles and pharmaceutical candidates.
Methyl 6-bromonicotinate serves as a versatile building block in synthetic organic chemistry, enabling palladium-catalyzed cross-coupling reactions for the construction of substituted pyridine scaffolds. The bromine substituent exhibits high reactivity in Suzuki, Stille, and Negishi couplings, while the ester group provides orthogonal functionality for further derivatization. Its bench-stable nature and compatibility with diverse reaction conditions make it a practical choice for medicinal chemistry and process development workflows.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: