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Structure of 262373-15-9
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4-Methyl-2-(trimethylsilyl)phenyl trifluoromethanesulfonate is a bench-stable silyl-protected aryl triflate featuring a methyl group at the ortho position. This configuration enhances regioselectivity in cross-coupling reactions, enabling efficient C–C bond formation under mild conditions. The trimethylsilyl moiety provides stability and facilitates subsequent desilylation.
4-Methyl-2-(trimethylsilyl)phenyl trifluoromethanesulfonate serves as a stable, bench-ready aryl triflate building block for palladium-catalyzed cross-coupling reactions. Its ortho-trimethylsilyl group enhances solubility and modulates reactivity, while the triflate moiety enables reliable Suzuki, Stille, and Negishi coupling protocols. The molecule exhibits excellent functional group tolerance and facilitates efficient construction of substituted biaryls and complex heterocycles in medicinal chemistry workflows.
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GHS Pictogram :
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GHS No : GHS05
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Signal Word : Danger
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UN#: 3265
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Class : 8
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Packing Group : Ⅱ
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Hazard Statements : H290-H314
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Precautionary Statements : P234-P260-P264-P280-P301+P330+P331-P304+P340-P363-P390-P405-P406-P501
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Lot numbers can be found on the outside label of a product: