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CS-W001157 4
Total: USD 88.00

2-Bromo-1-(2,4-dichlorophenyl)ethanone

  • CAS No. 2631-72-3

  • Cat. No. CS-M0784
  • Molecule weight267.93
  • Purity≥95%
  • MDL No.MFCD00053005

*For research and further manufacturing use only, not for direct human use.

2-Bromo-1-(2,4-dichlorophenyl)ethanone|CS-M0784

Structure of 2631-72-3

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General Information

  • CAS No. 2631-72-3
  • Cat. No. CS-M0784
  • Purity ≥95%
  • MDL No. MFCD00053005
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₅BrCl₂O
  • Molecular Weight 267.93
  • Synonym(s) α-Bromo-2,4-dichloroacetophenone
  • SMILES O=C(CBr)C1=C(Cl)C=C(Cl)C=C1

Description

2-Bromo-1-(2,4-dichlorophenyl)ethanone features a brominated ketone moiety flanked by a 2,4-dichlorophenyl group, delivering high reactivity for electrophilic substitution and cross-coupling transformations. This bench-stable compound integrates readily into synthetic routes requiring halogenated aryl ketones, offering reliable functionality under standard conditions.

Application

2-Bromo-1-(2,4-dichlorophenyl)ethanone serves as a versatile building block in synthetic organic chemistry, enabling the construction of pharmaceutically relevant heterocyclic scaffolds. Its bromoacetyl functionality facilitates nucleophilic substitution and transition-metal-catalyzed coupling reactions. The molecule exhibits good bench stability and compatibility with common protecting groups, making it suitable for multi-step synthesis workflows requiring functional group tolerance and predictable reactivity.

Synthesis

  • Route1
    • 1-(2,4-Dichlorophenyl)ethan-1-one Ketoconazole Impurity|CS-0528658
      2234-16-4
    • ~72%
    • Ketoconazole Impurity 38|CS-1003065
      24123-68-0
    • In-stock
      2-Bromo-1-(2,4-dichlorophenyl)ethanone|CS-M0784
      2631-72-3

    References

    • Prakash, G.K. Sxurya; Ismail, Rehana; Garcia, Jessica; Panja, Chiradeep; Rasul, Golam; Mathew, Thomas; Olah, George A. Tetrahedron Letters, 2011 , vol. 52, # 11 p. 1217 - 1221
  • Route2
    • 1-(2,4-Dichlorophenyl)ethan-1-one Ketoconazole Impurity|CS-0528658
      2234-16-4
    • ~99%
    • In-stock
      2-Bromo-1-(2,4-dichlorophenyl)ethanone|CS-M0784
      2631-72-3

    References

    • Rival; Taudou; Ecalle Farmaco, 1993 , vol. 48, # 6 p. 857 - 869
  • Route3
    • 1-(2,4-Dichlorophenyl)ethan-1-one Ketoconazole Impurity|CS-0528658
      2234-16-4
    • ~%
    • null|null
      60208-07-3
    • In-stock
      2-Bromo-1-(2,4-dichlorophenyl)ethanone|CS-M0784
      2631-72-3

    References

    • Kopka, Ihor E.; Li, Bing; Hagmann, William K. Patent: US2005/245554 A1, 2005 ; Location in patent: Page/Page column 33 ; US 20050245554 A1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05,GHS06
Signal Word : Danger
UN#: 3261
Class : 8
Packing Group : Ⅲ
Hazard Statements : H301-H315-H318-H335
Precautionary Statements : P280-P302+P352-P330

Quality Control

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Computational Chemistry Data

  • TPSA   17.07
  • LogP   3.571
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   2

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