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Structure of 26458-78-6
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Quinuclidine-4-carbonitrile is a sterically constrained, nitrogen-rich heterocycle featuring a pendant nitrile group. This configuration imparts enhanced nucleophilicity and favorable solubility in polar aprotic solvents. The molecule integrates readily into synthetic scaffolds requiring strong basicity with minimal steric interference.
Quinuclidine-4-carbonitrile serves as a versatile bifunctional building block in medicinal chemistry, combining a rigid, sterically constrained quinuclidine scaffold with a reactive nitrile group. The nitrile enables downstream transformations such as amidation, reduction to primary amine, or conversion to imidazoles and other heterocycles. Its bench-stable nature and compatibility with diverse reaction conditions facilitate efficient synthesis of complex scaffolds.
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GHS Pictogram :
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GHS No : GHS06
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Signal Word : Danger
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UN#: 3439
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Class : 6.1
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Packing Group : Ⅲ
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Hazard Statements : H301+H311+H331
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Precautionary Statements : P264-P270-P330-P405-P501
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Lot numbers can be found on the outside label of a product: