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Structure of 26893-12-9
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Ethyl 4-hydroxy-6-(trifluoromethyl)quinoline-3-carboxylate features a trifluoromethyl group enhancing electron-withdrawal and metabolic stability, while the hydroxyl moiety enables direct functionalization. This quinoline scaffold integrates readily into pharmaceutical intermediates, offering robustness under standard synthetic conditions and compatibility with transition-metal-catalyzed coupling reactions.
Ethyl 4-hydroxy-6-(trifluoromethyl)quinoline-3-carboxylate serves as a versatile building block in medicinal chemistry, enabling efficient access to quinoline-based scaffolds. The phenolic hydroxyl group facilitates direct functionalization or protection, while the trifluoromethyl and ester moieties offer enhanced metabolic stability and strategic reactivity for coupling reactions. Its bench-stable nature and compatibility with standard synthetic protocols make it ideal for iterative library synthesis and API development.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: