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CS-W001157 4
Total: USD 88.00

3,5-Difluorophenol

  • CAS No. 2713-34-0

  • Cat. No. CS-D1731
  • Molecule weight130.09
  • Purity≥98%
  • MDL No.MFCD00002255

*For research and further manufacturing use only, not for direct human use.

3,5-Difluorophenol|CS-D1731

Structure of 2713-34-0

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General Information

  • CAS No. 2713-34-0
  • Cat. No. CS-D1731
  • Purity ≥98%
  • MDL No. MFCD00002255
  • Storage RT, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₄F₂O
  • Molecular Weight 130.09
  • Synonym(s) Phenol, 3,5-difluoro-
  • SMILES OC1=CC(F)=CC(F)=C1

Description

3,5-Difluorophenol is a bench-stable, electron-deficient phenolic compound featuring two fluorine atoms at the 3- and 5-positions. This substitution pattern enhances metabolic stability and modulates reactivity, enabling selective functionalization in synthetic routes. The molecule integrates readily into pharmaceutical intermediates and bioactive scaffolds where halogenation and hydrogen bonding are key design elements.

Application

3,5-Difluorophenol serves as a versatile building block in medicinal chemistry, enabling the construction of fluorinated aromatic scaffolds through standard electrophilic substitution and coupling reactions. Its enhanced metabolic stability and favorable lipophilicity profile make it valuable for optimizing drug candidates. The compound exhibits good bench stability, facilitates straightforward purification, and demonstrates broad functional group tolerance in common synthetic transformations.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   20.23
  • LogP   1.6704
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   0

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