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Structure of 276694-19-0
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This oxadiazole derivative features a boronate ester group enabling efficient Suzuki-Miyaura coupling under standard conditions. The 1,3,4-oxadiazole ring imparts metabolic stability and enhances solubility, while the tetramethylcyclopentadienylboronate moiety ensures high reactivity and bench-stable handling.
2-(4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)-1,3,4-oxadiazole serves as a versatile boronate building block for palladium-catalyzed cross-coupling reactions. Its stable dioxaborolane group enables efficient Suzuki-Miyaura coupling with aryl halides and pseudohalides, facilitating the construction of biaryl scaffolds common in pharmaceutical and agrochemical research. The 1,3,4-oxadiazole ring provides metabolic stability and hydrogen-bonding capacity, enhancing its utility in medicinal chemistry lead optimization. Bench-stable and easily purified by flash chromatography, it functions reliably in multi-step syntheses requiring functional group tolerance and predictable reactivity.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: