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Structure of 27913-99-1
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4-(4-Methylpiperazin-1-yl)benzaldehyde features a para-substituted benzaldehyde core linked to a sterically accessible methylpiperazine group, enabling efficient coupling in late-stage functionalization. This electron-rich scaffold integrates readily into bioactive molecule frameworks, offering enhanced solubility and metabolic stability in medicinal chemistry applications.
4-(4-Methylpiperazin-1-yl)benzaldehyde serves as a versatile building block in medicinal chemistry, enabling efficient access to bioactive heterocycles and drug-like scaffolds. The aldehyde functionality facilitates reductive amination, Schiff base formation, and coupling reactions with amines or hydrazides. Its piperazine moiety provides solubility enhancement and hydrogen-bonding capacity, while the methylpiperazine group offers favorable pharmacokinetic properties. Bench-stable and readily purified by recrystallization or chromatography, it functions effectively in standard synthetic workflows for lead optimization and API intermediate development.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: