2-Bromo-6-hydroxypyridine

Name: 2-Bromo-6-hydroxypyridine
Brand: ChemScene
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CAS No. 27992-32-1
Cat. No. CS-W002547
Purity≥97%
MDL No.MFCD11226855

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

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Structure of 27992-32-1

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Description

2-Bromo-6-hydroxypyridine features a strategically positioned hydroxyl group adjacent to a bromine atom on the pyridine ring, enabling selective functionalization in cross-coupling and nucleophilic substitution reactions. This electron-deficient heterocycle integrates readily into complex molecular architectures under mild conditions, offering high reactivity with minimal side pathways.

Application

2-Bromo-6-hydroxypyridine serves as a versatile building block in heterocyclic synthesis, enabling direct functionalization at the C6 position via nucleophilic substitution or transition-metal-catalyzed coupling. The bromo group facilitates Pd-catalyzed cross-coupling reactions, while the hydroxyl moiety offers site-specific derivatization potential. Its bench-stable nature and compatibility with common protecting group strategies make it a practical choice for medicinal chemistry and process development workflows.

General Information

CAS No. 27992-32-1
Cat. No. CS-W002547
Purity ≥97%
MDL No. MFCD11226855
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₅H₄BrNO
Molecular Weight 174.00
Synonym(s) 6-Bromo-2-pyridone
SMILES OC1=CC=CC(Br)=N1

Computational Chemistry Data

TPSA 33.12
LogP 1.5497
H_Acceptors 2
H_Donors 1
Rotatable_Bonds 0

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Other Classifications

Building Blocks Functional Group Bromide

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

Key Words

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2-Bromo-6-hydroxypyridine

CAS No. 27992-32-1

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