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CS-W001157 4
Total: USD 88.00

4,6-Difluoropyrimidine

  • CAS No. 2802-62-2

  • Cat. No. CS-0132157
  • Purity≥97%
  • MDL No.MFCD03412223
  • HazMat Fee +

    HazMat Fee

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

4,6-Difluoropyrimidine|CS-0132157

Structure of 2802-62-2

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Description

4,6-Difluoropyrimidine serves as a key heterocyclic scaffold in medicinal chemistry, offering enhanced metabolic stability and improved binding affinity due to its electron-deficient nature. This bench-stable, moisture-tolerant compound integrates readily into kinase inhibitors and antiviral agents, enabling efficient coupling in late-stage functionalization.

Application

4,6-Difluoropyrimidine serves as a versatile building block in medicinal chemistry, enabling efficient late-stage functionalization via nucleophilic substitution. Its dual fluorine substituents provide high reactivity at C4 and C6 positions while maintaining bench stability and compatibility with diverse reaction conditions. The compound functions as a key scaffold for constructing bioactive heterocycles and facilitates the synthesis of pharmaceutical intermediates through orthogonal coupling strategies.

General Information

  • CAS No. 2802-62-2
  • Cat. No. CS-0132157
  • Purity ≥97%
  • MDL No. MFCD03412223
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₄H₂F₂N₂
  • Molecular Weight 116.07
  • Synonym(s) Pyrimidine, 4,6-difluoro-
  • SMILES FC1=CC(F)=NC=N1

Computational Chemistry Data

  • TPSA   25.78
  • LogP   0.7548
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   0

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05
Signal Word : Danger
UN#: 1760
Class : 8
Packing Group :
Hazard Statements : H318
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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