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Structure of 280566-45-2
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2-Chloro-6-trifluoromethylnicotinic acid features a trifluoromethyl group at the pyridine ring's C6 position, imparting enhanced electron-withdrawing character and metabolic stability. This structural motif enables efficient incorporation into bioactive molecules, particularly in medicinal chemistry scaffolds requiring halogenated heterocycles. The compound exhibits favorable solubility under standard conditions and serves as a key intermediate for pharmaceutical development workflows.
2-Chloro-6-trifluoromethylnicotinic acid serves as a versatile building block in medicinal chemistry, enabling the synthesis of bioactive heterocycles and pharmaceutical intermediates. Its electron-deficient pyridine core facilitates nucleophilic aromatic substitution, while the trifluoromethyl group enhances metabolic stability and lipophilicity. The carboxylic acid functionality supports direct coupling reactions or derivatization, offering excellent bench stability and compatibility with standard purification methods.
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GHS Pictogram :
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GHS No : GHS06
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Signal Word : Danger
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UN#: 2811
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Class : 6.1
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Packing Group : Ⅲ
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Hazard Statements : H301-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362-P405-P501
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Lot numbers can be found on the outside label of a product: