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CS-W001157 4
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2,4-Dichloro-5-ethoxypyrimidine

  • CAS No. 280582-25-4

  • Cat. No. CS-0139663
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

2,4-Dichloro-5-ethoxypyrimidine|CS-0139663

Structure of 280582-25-4

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General Information

  • CAS No. 280582-25-4
  • Cat. No. CS-0139663
  • Purity ≥97%
  • MDL No. None
  • Storage -20°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₆Cl₂N₂O
  • Molecular Weight 193.03
  • Synonym(s) Pyrimidine,2,4-dichloro-5-ethoxy
  • SMILES CCOC1=CN=C(Cl)N=C1Cl

Description

2,4-Dichloro-5-ethoxypyrimidine features a pyrimidine core bearing two chlorine substituents and a terminal ethoxy group, enabling selective coupling reactions in medicinal chemistry. This electron-deficient heterocycle serves as a key intermediate for synthesizing kinase inhibitors and antiviral agents, offering high reactivity under mild conditions with excellent functional group tolerance.

Application

2,4-Dichloro-5-ethoxypyrimidine serves as a versatile building block in heterocyclic synthesis, enabling efficient construction of pyrimidine-based scaffolds. Its dual chloro substituents facilitate nucleophilic substitution reactions under mild conditions, while the ethoxy group enhances solubility and stability. This compound functions effectively in Pd-catalyzed cross-coupling and amination processes, offering reliable access to substituted pyrimidines relevant to agrochemical and medicinal chemistry applications.

Synthesis

  • Route1
    • null|null
      7248-96-6
    • ~36%
    • In-stock
      2,4-Dichloro-5-ethoxypyrimidine|CS-0139663
      280582-25-4

    References

    • DEVELOPMENT CENTER FOR BIOTECHNOLOGY; DCB-USA LLC; KUO, Mann-Yan; LEE, Ying-Shuan; CHEN, Paonien; CHEN, Li Jung; LU, Yann Yu; HUANG, Yi-Ting; HSU, Hung-Yi; TSAI, Ping-Kuei Patent: WO2011/80568 A2, 2011 ; Location in patent: Page/Page column 142 ; WO 2011/080568 A2
  • Route2
    • null|null
      7248-96-6
    • null|null
      10025-87-3
    • ~%
    • In-stock
      2,4-Dichloro-5-ethoxypyrimidine|CS-0139663
      280582-25-4

    References

    • Johnson; Guest American Chemical Journal, 1909 , vol. 42, p. 284

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   35.01
  • LogP   2.1821
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   2

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