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CS-W001157 4
Total: USD 88.00

H-Pro-OtBu

  • CAS No. 2812-46-6

  • Cat. No. CS-W007677
  • Molecule weight171.24
  • Purity≥97%
  • MDL No.MFCD00037879

*For research and further manufacturing use only, not for direct human use.

H-Pro-OtBu|CS-W007677

Structure of 2812-46-6

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General Information

  • CAS No. 2812-46-6
  • Cat. No. CS-W007677
  • Purity ≥97%
  • MDL No. MFCD00037879
  • Storage -20°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₁₇NO₂
  • Molecular Weight 171.24
  • Synonym(s) Tert-butyl pyrrolidine-2-carboxylate; H-Pro-OtBu
  • SMILES O=C(OC(C)(C)C)[C@H]1NCCC1

Description

H-Pro-OtBu is a bench-stable, moisture-tolerant amino acid derivative featuring a tert-butyl-protected proline moiety. This robust building block integrates seamlessly into peptide synthesis workflows, enabling efficient access to Pro-containing sequences with minimal side-reaction risk under standard conditions.

Synthesis

  • Route1

    References

    • Murata, Makoto; Hara, Takayoshi; Mori, Kohsuke; Ooe, Masahiko; Mizugaki, Tomoo; Ebitani, Kohki; Kaneda, Kiyotomi Tetrahedron Letters, 2003 , vol. 44, # 27 p. 4981 - 4984
  • Route2
    • Boc-Pyr-OtBu|CS-0915008
      91237-84-2
    • ~88%
    • In-stock
      H-Pro-OtBu|CS-W007677
      2812-46-6

    References

    • Bose, D. Subhas; Kumar, K. Kiran; Reddy, A.V. Narsimha Synthetic Communications, 2003 , vol. 33, # 3 p. 445 - 450
  • Route3
    • null|null
      115-11-7
    • L-Proline Enalapril  Impurity|CS-0229432
      147-85-3
    • ~%
    • In-stock
      H-Pro-OtBu|CS-W007677
      2812-46-6

    References

    • Merck and Co., Inc. Patent: US4992541 A1, 1991 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05,GHS07
Signal Word : Danger
UN#: 1760
Class : 8
Packing Group : Ⅲ
Hazard Statements : H302-H315-H318-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   38.33
  • LogP   1.0801
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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