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Structure of 28186-62-1
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3-Iodo-5-(trifluoromethyl)benzoic acid features a sterically hindered aromatic core with complementary electronic effects: the electron-withdrawing trifluoromethyl group enhances electrophilicity at the para-position, while the iodine substituent enables facile cross-coupling. This combination facilitates efficient incorporation into complex molecular architectures under standard conditions.
3-Iodo-5-(trifluoromethyl)benzoic acid serves as a versatile building block for the synthesis of bioactive heterocycles and pharmaceutical intermediates. Its iodine and trifluoromethyl groups enable palladium-catalyzed cross-coupling reactions, while the carboxylic acid facilitates derivatization via amide or ester formation. The molecule exhibits excellent bench stability and compatibility with standard synthetic workflows, enabling efficient access to complex scaffolds in medicinal chemistry and process development.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: