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Structure of 2820537-15-1
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This fluorinated pyrrolizidine derivative features a stereodefined hydroxymethyl group at the 7a-position, delivering enhanced metabolic stability and improved solubility in polar solvents. The (2S,7aS) configuration ensures precise spatial orientation for targeted interactions in synthetic intermediates. This scaffold integrates readily into bioactive molecule frameworks where controlled polarity and conformational rigidity are critical.
((2S,7aS)-2-Fluorohexahydro-1H-pyrrolizin-7a-yl)methanol serves as a stereochemically defined building block for fluorinated nitrogen heterocycles. Its bench-stable, chiral pyrrolizidine core enables selective functionalization and acts as a versatile scaffold in medicinal chemistry synthesis. The hydroxymethyl group facilitates derivatization via standard coupling reactions, while the fluorine substituent enhances metabolic stability and modulates electronic properties—key attributes for optimizing pharmacophores in target-directed compound libraries.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
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Lot numbers can be found on the outside label of a product: