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Structure of 2825012-62-0
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This trifluoromethyl-substituted bicyclic carboxylic acid features a rigid, electron-deficient scaffold ideal for probing steric and electronic effects in medicinal chemistry. The oxabicyclic core provides structural stability, while the para-trifluoromethyl group enhances metabolic resistance and lipophilicity. Designed for direct incorporation into bioactive molecules, it enables precise modulation of pharmacokinetic properties in lead optimization campaigns.
1-(Trifluoromethyl)-2-oxabicyclo[2.2.2]octane-4-carboxylic acid serves as a rigid, electron-deficient bicyclic building block for medicinal chemistry and materials science. Its trifluoromethyl group enhances metabolic stability and lipophilicity, while the carboxylic acid functionality enables direct coupling or derivatization. The oxabicyclic core provides conformational restraint, facilitating structure-activity relationship studies. Bench-stable and compatible with standard peptide coupling protocols, it functions effectively in diverse synthetic workflows requiring defined spatial orientation and enhanced physicochemical properties.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: