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CS-W001157 4
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Gamma-glutamylcysteine TFA

  • CAS No. 283159-88-6

  • Cat. No. CS-0101974
  • Molecule weight364.30
  • Purity≥95%
  • MDL No.MFCD00133357

*For research and further manufacturing use only, not for direct human use.

Gamma-glutamylcysteine TFA|CS-0101974

Structure of 283159-88-6

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General Information

  • CAS No. 283159-88-6
  • Cat. No. CS-0101974
  • Purity ≥95%
  • MDL No. MFCD00133357
  • Storage polypeptide, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₁₅F₃N₂O₇S
  • Molecular Weight 364.30
  • Synonym(s) γ-Glu-Cys (TFA)
  • SMILES SC[C@@H](C(O)=O)NC(CC[C@H](N)C(O)=O)=O.OC(C(F)(F)F)=O

Description

Gamma-glutamylcysteine (TFA) is a key intermediate in glutathione biosynthesis, featuring a stable gamma-peptide bond and a trifluoroacetate counterion for enhanced solubility. This dipeptide derivative bears a reactive thiol group ideal for conjugation chemistry and maintains stability under standard bench conditions, enabling reliable use in biochemical assays and metabolic studies.

Application

Gamma-glutamylcysteine (TFA) serves as a key tripeptide precursor in glutathione biosynthesis, enabling efficient synthesis of reduced glutathione (GSH) and related thiol-containing compounds. The TFA salt enhances solubility and stability in aqueous systems, facilitating its use in enzymatic assays, redox biology studies, and peptide coupling workflows. Its amide-linked gamma-glutamyl moiety ensures compatibility with standard peptide protection strategies and supports reliable incorporation into larger bioactive scaffolds.

Safety Information

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Computational Chemistry Data

  • TPSA   167.02
  • LogP   -0.689
  • H_Acceptors   6
  • H_Donors   6
  • Rotatable_Bonds   7

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