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CS-W001157 4
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2-Phenylglycine

  • CAS No. 2835-06-5

  • Cat. No. CS-W010964
  • Purity≥96%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

2-Phenylglycine|CS-W010964

Structure of 2835-06-5

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General Information

  • CAS No. 2835-06-5
  • Cat. No. CS-W010964
  • Purity ≥96%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₉NO₂
  • Molecular Weight 151.16
  • Synonym(s) DL-α-Phenylglycine
  • SMILES O=C(O)C(N)C1=CC=CC=C1

Description

2-Phenylglycine serves as a key chiral building block in the synthesis of pharmaceuticals and bioactive molecules. Featuring a phenyl-substituted alpha-carbon, this compound integrates readily into peptide architectures and offers enhanced metabolic stability. The benzylic proton exhibits moderate acidity, enabling selective functionalization under mild conditions.

Application

2-Phenylglycine serves as a valuable chiral building block in medicinal chemistry, enabling the synthesis of diverse β-phenylalanine derivatives. Its structure supports straightforward functionalization at both the amino and carboxyl termini, with good bench stability and compatibility across standard coupling protocols. The compound functions effectively in peptide synthesis and as a precursor to pharmaceutically relevant heterocyclic scaffolds.

Synthesis

  • Route1

    References

    • US2010/234596 A1, ; Page/Page column 14 ;
  • Route2
    • null|null
      6485-63-8
    • ~91%
    • In-stock
      2-Phenylglycine|CS-W010964
      2835-06-5

    References

    • Tetrahedron, , vol. 69, # 47 p. 10091 - 10097
  • Route3
    • null|null
      93732-92-4
    • ~95%
    • In-stock
      2-Phenylglycine|CS-W010964
      2835-06-5

    References

    • Chemical Communications, , # 34 p. 4052 - 4054

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   63.32
  • LogP   0.771
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   2

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