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Structure of 28489-45-4
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6-Hydroxy-3-nitro-2-picoline features a hydroxyl group at the 6-position and a nitro substituent at the 3-position on a picoline core, enabling dual reactivity. This electron-deficient heterocycle integrates readily into synthetic sequences requiring polar functional handles. The molecule exhibits enhanced solubility in aqueous and protic solvents, facilitating use in medicinal chemistry and process development workflows under standard conditions.
6-Hydroxy-3-nitro-2-picoline serves as a versatile building block in medicinal chemistry, enabling direct functionalization at the hydroxyl group and facilitating subsequent derivatization via etherification or esterification. Its ortho-nitro substitution enhances electrophilic reactivity, supporting regioselective transformations. The compound exhibits good bench stability and is compatible with standard purification techniques, making it well-suited for iterative synthesis workflows in API development.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: