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Structure of 2849-93-6
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1H-Benzimidazole-2-carboxylic acid features a fused heterocyclic core with a carboxylic acid group at the 2-position, enabling direct integration into bioactive scaffolds. This rigid, electron-deficient architecture supports hydrogen bonding and π-stacking interactions, enhancing binding affinity in target-directed synthesis. The moiety exhibits bench-stable handling and compatibility with diverse coupling protocols, facilitating rapid access to functionalized derivatives for medicinal chemistry campaigns.
1H-Benzimidazole-2-carboxylic acid serves as a versatile building block for the synthesis of biologically active heterocycles and pharmaceutical intermediates. Its carboxylic acid functionality enables direct coupling reactions, while the benzimidazole core provides structural rigidity and hydrogen-bonding capacity. The compound exhibits good bench stability and facilitates efficient purification, making it well-suited for iterative synthetic workflows in medicinal chemistry and process development.
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GHS Pictogram :
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GHS No : GHS05,GHS07
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Signal Word : Danger
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UN#: 3261
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Class : 8
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Packing Group : Ⅲ
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Hazard Statements : H302-H315-H318-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
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Lot numbers can be found on the outside label of a product: