5-Bromo-2,4-difluorobenzene-1-sulfonyl chloride

Name: 5-Bromo-2,4-difluorobenzene-1-sulfonyl chloride
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 287172-61-6
Cat. No. CS-0020142
Purity≥97%
MDL No.MFCD01940424

HazMat Fee +

HazMat Fee

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

The shipment is processed through FedEx Ground under the Limited Quantity option.

Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

5-Bromo-2,4-difluorobenzene-1-sulfonyl chloride|CS-0020142

Structure of 287172-61-6

Size

Price

Quantity

* Please select Quantity before adding items.

Description

5-Bromo-2,4-difluorobenzene-1-sulfonyl chloride is a fluorinated sulfonyl chloride featuring orthogonal reactivity and enhanced electrophilicity. This bench-stable reagent integrates readily into synthetic pathways requiring selective sulfonamide formation under mild conditions. Its electron-deficient aromatic core facilitates efficient coupling with nucleophiles while maintaining stability during handling.

Application

5-Bromo-2,4-difluorobenzene-1-sulfonyl chloride serves as a versatile building block for the synthesis of sulfonamide-containing pharmaceutical intermediates. Its reactivity is enabled by the electrophilic sulfonyl chloride group, which readily undergoes nucleophilic substitution with amines under mild conditions. The presence of bromo and difluoro substituents provides orthogonal functionalization potential and enhances metabolic stability in downstream applications. This compound exhibits good bench stability and facilitates straightforward purification, making it well-suited for use in medicinal chemistry campaigns and process-scale syntheses.

General Information

CAS No. 287172-61-6
Cat. No. CS-0020142
Purity ≥97%
MDL No. MFCD01940424
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₆H₂BrClF₂O₂S
Molecular Weight 291.50
Synonym(s) 5-Bromo-2,4-difluorobenzenesulfonyl chloride
SMILES O=S(C1=CC(Br)=C(F)C=C1F)(Cl)=O

Computational Chemistry Data

TPSA 34.14
LogP 2.6548
H_Acceptors 2
H_Donors 0
Rotatable_Bonds 1

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS05
Signal Word : Danger	UN#: 3261
Class : 8	Packing Group : Ⅱ
Hazard Statements : H314-H318
Precautionary Statements : P260-P264-P280-P301+P330+P331-P303+P361+P353-P304+P340-P305+P351+P338-P363-P405-P501

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Other Classifications

Building Blocks Functional Group Sulfonyl Chloride

Building Blocks Functional Group Bromide

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Key Words

287172-61-6 sigma287172-61-6 manufacturer287172-61-6 price287172-61-6 structure287172-61-6 SDSbuy 287172-61-6287172-61-6 supplier287172-61-6 uses287172-61-6 molecular weightprice of 287172-61-6287172-61-6 chemical name formula of 287172-61-6

Salutation:	*Country or Region:
*Applicant Name:	*Organization Name:
*Email Address:	Quantity:
CAS NO. :	Product Name:
Remarks:
Upload Pictures

CAS.No.		Product Name
Applicant Name *		Email Address *
Phone Number *		Organization Name*
Country or Region*		Quantity*
Remarks:

Product Name:
Cat. No.: .		CAS NO. :
Quantity:

5-Bromo-2,4-difluorobenzene-1-sulfonyl chloride

CAS No. 287172-61-6

Recommended Products