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Structure of 288151-68-8
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8-Fluoro-2-methylquinoline-4-carboxylic acid features a fluorine atom at the 8-position and a methyl group at the 2-position, enhancing electronic modulation and metabolic stability. This electron-deficient quinoline scaffold integrates readily into pharmaceutical scaffolds, enabling efficient coupling in late-stage functionalization. The carboxylic acid moiety facilitates conjugation via amide or ester linkages under standard conditions.
8-Fluoro-2-methylquinoline-4-carboxylic acid serves as a versatile building block in medicinal chemistry, enabling the construction of bioactive heterocyclic scaffolds. Its orthogonal functionalization profile—combining an electron-deficient quinoline core with fluorine-directed regioselectivity and a carboxylic acid for derivatization—facilitates efficient synthesis of kinase inhibitors and other pharmaceutical candidates. The compound exhibits excellent bench stability and compatibility with standard coupling protocols, supporting scalable route development.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
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Lot numbers can be found on the outside label of a product: