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CS-W001157 4
Total: USD 88.00

3-Chlorobenzenesulfonyl chloride

  • CAS No. 2888-06-4

  • Cat. No. CS-W015070
  • Purity≥98%
  • MDL No.MFCD00051697

*For research and further manufacturing use only, not for direct human use.

3-Chlorobenzenesulfonyl chloride|CS-W015070

Structure of 2888-06-4

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General Information

  • CAS No. 2888-06-4
  • Cat. No. CS-W015070
  • Purity ≥98%
  • MDL No. MFCD00051697
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₄Cl₂O₂S
  • Molecular Weight 211.06
  • Synonym(s) m-chlorobenzenesulfonyl chloride
  • SMILES O=S(C1=CC=CC(Cl)=C1)(Cl)=O

Description

3-Chlorobenzenesulfonyl chloride is a bench-stable, moisture-tolerant reagent featuring a sulfonyl chloride group ortho to a chlorine substituent. This electron-deficient arylsulfonyl moiety enables efficient coupling in sulfonamide synthesis and serves as a key intermediate in pharmaceutical process development.

Application

3-Chlorobenzenesulfonyl chloride serves as a versatile sulfonylating agent for the efficient introduction of the 3-chlorobenzenesulfonyl group into nucleophiles. It enables reliable formation of sulfonamides and sulfonate esters under mild conditions, with good bench stability and straightforward purification. Its functional group tolerance supports integration into complex molecule synthesis, particularly in medicinal chemistry and heterocycle construction workflows.

Synthesis

  • Route1

    References

    • Pu, Yu-Ming; Christesen, Alan; Ku, Yi-Yin Tetrahedron Letters, 2010 , vol. 51, # 2 p. 418 - 421
  • Route2
    • null|null
      108-42-9
    • ~39%
    • In-stock
      3-Chlorobenzenesulfonyl chloride|CS-W015070
      2888-06-4

    References

    • Larkin, Finbar G.; More O'Ferrall, Rory A.; Murphy, Donal G. Collection of Czechoslovak Chemical Communications, 1999 , vol. 64, # 11 p. 1833 - 1848
  • Route3
    • Sodium 3-aminobenzenesulfonate|CS-0451323
      1126-34-7
    • ~%
    • In-stock
      3-Chlorobenzenesulfonyl chloride|CS-W015070
      2888-06-4

    References

    • Journal of Organic Chemistry, , vol. 26, p. 4331 - 4336

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05
Signal Word : Danger
UN#: 3265
Class : 8
Packing Group : Ⅱ
Hazard Statements : H314
Precautionary Statements : P264-P280-P301+P330+P331-P304+P340-P363-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   34.14
  • LogP   2.2675
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   1

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