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Structure of 289039-82-3
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5-Chloro-2-iodobenzoic acid methyl ester features a strategically positioned iodine atom enabling efficient cross-coupling reactions. The chloro substituent enhances electronic modulation, while the methyl ester group offers improved solubility and stability under standard conditions. This compound serves as a key intermediate in synthesizing functionalized aromatic systems for pharmaceutical and materials applications.
5-Chloro-2-iodobenzoic acid methyl ester serves as a versatile building block in cross-coupling chemistry, enabling efficient palladium-catalyzed transformations such as Suzuki-Miyaura and Stille reactions. The iodide group provides high reactivity under standard conditions, while the chloro and ester functionalities offer orthogonal handles for further functionalization. Bench-stable and amenable to purification by flash chromatography, it facilitates the construction of complex biaryl and heterocyclic scaffolds relevant to medicinal chemistry and materials science.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: