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CS-W001157 4
Total: USD 88.00

[(2,6-Dimethylphenyl)Carbamoyl]Formic acid

  • CAS No. 2903-48-2

  • Cat. No. CS-0040346
  • Purity≥98%
  • MDL No.MFCD10018453

*For research and further manufacturing use only, not for direct human use.

[(2,6-Dimethylphenyl)Carbamoyl]Formic acid|CS-0040346

Structure of 2903-48-2

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General Information

  • CAS No. 2903-48-2
  • Cat. No. CS-0040346
  • Purity ≥98%
  • MDL No. MFCD10018453
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₁₁NO₃
  • Molecular Weight 193.20
  • Synonym(s) N-(2,6-Dimethylphenyl)oxamic Acid
  • SMILES O=C(O)C(NC1=C(C)C=CC=C1C)=O

Description

This carbamoylformic acid derivative features a sterically hindered aryl group that enhances stability and modulates reactivity. The combined electron-withdrawing nature of the formyl and carbamoyl functionalities enables precise tuning for use in synthetic intermediates, particularly within peptide coupling and heterocycle formation workflows.

Application

[(2,6-Dimethylphenyl)carbamoyl]formic acid serves as a versatile building block for heterocyclic synthesis, particularly in the construction of substituted ureas and amidines. Its formyl group enables facile condensation reactions, while the ortho-dimethylphenyl carbamoyl moiety provides steric protection and enhanced stability under standard reaction conditions. The molecule exhibits excellent bench stability and facilitates straightforward purification, making it well-suited for iterative synthetic workflows in medicinal chemistry and process development.

Synthesis

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      [(2,6-Dimethylphenyl)Carbamoyl]Formic acid|CS-0040346
      2903-48-2

    References

    • Ferrando-Soria, Jesaus; Pardo, Emilio; Ruiz-Garcia, Rafael; Cano, Joan; Lloret, Francisco; Julve, Miguel; Journaux, Yves; Pasan, Jorge; Ruiz-Perez, Catalina Chemistry - A European Journal, 2011 , vol. 17, # 7 p. 2176 - 2188

Safety Information

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GHS Pictogram :
GHS No : GHS07,GHS08,GHS09
Signal Word : Danger
UN#: 3077
Class : 9
Packing Group : Ⅲ
Hazard Statements : H302-H372-H411
Precautionary Statements : P260-P264-P273-P391-P501

Quality Control

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Computational Chemistry Data

  • TPSA   66.4
  • LogP   1.32654
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   1

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