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CS-W001157 4
Total: USD 88.00

4-Methoxypicolinic acid

  • CAS No. 29082-91-5

  • Cat. No. CS-W005027
  • Purity≥98%
  • MDL No.MFCD04115716

*For research and further manufacturing use only, not for direct human use.

4-Methoxypicolinic acid|CS-W005027

Structure of 29082-91-5

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General Information

  • CAS No. 29082-91-5
  • Cat. No. CS-W005027
  • Purity ≥98%
  • MDL No. MFCD04115716
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₇NO₃
  • Molecular Weight None
  • Synonym(s) 4-methoxypyridine-2-carboxylate
  • SMILES O=C(O)C1=NC=CC(OC)=C1

Description

4-Methoxypicolinic acid features a pyridine ring with strategically positioned electron-withdrawing and electron-donating groups, enhancing its utility in synthetic organic chemistry. The methoxy substituent improves solubility and stability under standard conditions, while the carboxylic acid functionality enables direct coupling reactions. This compound serves as a key building block for bioactive heterocycles and pharmaceutical intermediates.

Application

4-Methoxypicolinic acid serves as a versatile building block in medicinal chemistry, enabling efficient synthesis of pyridine-based heterocycles and bioactive scaffolds. Its methoxy group enhances solubility and modulates electronic properties, while the carboxylic acid functionality facilitates direct coupling reactions or derivatization. The compound exhibits excellent bench stability and compatibility with standard peptide coupling protocols, making it ideal for iterative synthetic campaigns in API development.

Synthesis

  • Route1
    • null|null
      67-56-1
    • In-stock
      4-Nitropicolinic acid|CS-W002500
      13509-19-8
    • ~99%
    • In-stock
      4-Methoxypicolinic acid|CS-W005027
      29082-91-5

    References

    • Hayashi, Masashi; Shiomi, Noriyuki; Funahashi, Yasuhiro; Nakamura, Shuichi Journal of the American Chemical Society, 2012 , vol. 134, # 47 p. 19366 - 19369
  • Route2
    • null|null
      694-59-7
    • ~%
    • In-stock
      4-Methoxypicolinic acid|CS-W005027
      29082-91-5

    References

    • Desjardins, Sylvie Y.; Cavell, Kingsley J.; Hoare, Jason L.; Skelton, Brian W.; Sobolev, Alexander N.; White, Allan H.; Keim, Wilhelm Journal of Organometallic Chemistry, 1997 , vol. 544, # 2 p. 163 - 174
  • Route3
    • null|null
      1124-33-0
    • ~%
    • In-stock
      4-Methoxypicolinic acid|CS-W005027
      29082-91-5

    References

    • Hayashi, Masashi; Shiomi, Noriyuki; Funahashi, Yasuhiro; Nakamura, Shuichi Journal of the American Chemical Society, 2012 , vol. 134, # 47 p. 19366 - 19369

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   59.42
  • LogP   0.7884
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   2

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