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CS-W001157 4
Total: USD 88.00

Cyclobutanol

  • CAS No. 2919-23-5

  • Cat. No. CS-W013758
  • Purity≥98%
  • MDL No.MFCD00001318

*For research and further manufacturing use only, not for direct human use.

Cyclobutanol|CS-W013758

Structure of 2919-23-5

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General Information

  • CAS No. 2919-23-5
  • Cat. No. CS-W013758
  • Purity ≥98%
  • MDL No. MFCD00001318
  • Storage -20°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₄H₈O
  • Molecular Weight 72.11
  • Synonym(s) None
  • SMILES OC1CCC1

Description

Cyclobutanol is a strained four-membered cyclic alcohol featuring a hydroxyl group bonded to a highly reactive cyclobutane ring. This structural rigidity imparts unique reactivity in synthetic transformations, enabling selective functionalization under mild conditions. The molecule exhibits enhanced polarity compared to its acyclic counterparts, improving solubility in polar solvents while maintaining compatibility with standard anhydrous protocols.

Application

Cyclobutanol serves as a versatile building block in synthetic organic chemistry, enabling the construction of strained cyclic systems and functionalized intermediates. Its hydroxyl group facilitates standard transformations such as oxidation, substitution, and protection, while the cyclobutane ring provides unique conformational constraints valuable in medicinal chemistry. Bench-stable and amenable to purification by distillation or chromatography, it functions reliably in multi-step syntheses requiring controlled reactivity and moderate ring strain.

Synthesis

  • Route1
    • null|null
      1191-95-3
    • ~55%
    • In-stock
      Cyclobutanol|CS-W013758
      2919-23-5

    References

    • Yeda Research and Development Co. Ltd. Patent: US3980718 A1, 1976 ;
  • Route2
    • null|null
      70458-21-8
    • ~6%
    • null|null
      70458-29-6
    • null|null
      70458-27-4
    • null|null
      70458-28-5
    • In-stock
      Cyclobutanol|CS-W013758
      2919-23-5

    References

    • Barbas, John T.; Leffler, John E. Journal of Organic Chemistry, 1991 , vol. 56, # 11 p. 3722 - 3723
  • Route3
    • null|null
      76387-45-6
    • ~%
    • null|null
      627-27-0
    • null|null
      2516-33-8
    • In-stock
      Cyclobutanol|CS-W013758
      2919-23-5

    References

    • Sieh, David H.; Michejda, Christopher J. Journal of the American Chemical Society, 1981 , vol. 103, # 2 p. 442 - 445

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS02
Signal Word : Danger
UN#: 1987
Class : 3
Packing Group : Ⅱ
Hazard Statements : H225
Precautionary Statements : P210-P233-P240-P241-P242-P243-P280-P370+P378-P501

Quality Control

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Computational Chemistry Data

  • TPSA   20.23
  • LogP   0.5312
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   0

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