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CS-W001157 4
Total: USD 88.00

3,5-Dibromo-2-methylthiophene

  • CAS No. 29421-73-6

  • Cat. No. CS-0109443
  • Purity≥96%
  • MDL No.MFCD07781197

*For research and further manufacturing use only, not for direct human use.

3,5-Dibromo-2-methylthiophene|CS-0109443

Structure of 29421-73-6

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General Information

  • CAS No. 29421-73-6
  • Cat. No. CS-0109443
  • Purity ≥96%
  • MDL No. MFCD07781197
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₄Br₂S
  • Molecular Weight 255.96
  • Synonym(s) 2-METHYL-3,5-DIBROMO-THIOPHENE
  • SMILES CC1=C(Br)C=C(Br)S1

Description

3,5-Dibromo-2-methylthiophene is a brominated thiophene derivative featuring two bromine substituents at the 3 and 5 positions and a methyl group at the 2 position. This electron-deficient heterocycle integrates readily into cross-coupling reactions, offering high functional group tolerance and stability under standard conditions. The para-bromine pairs enable sequential derivatization, while the methylthio moiety enhances solubility and modulates reactivity in synthetic sequences.

Application

3,5-Dibromo-2-methylthiophene serves as a versatile building block for the synthesis of functionalized heterocycles and pharmaceutical intermediates. Its brominated positions enable palladium-catalyzed cross-coupling reactions with broad functional group tolerance, while the methylthio group offers stability and mild reactivity. The compound exhibits excellent bench stability and facilitates efficient purification, making it well-suited for iterative synthetic workflows in medicinal chemistry and materials science applications.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   0
  • LogP   3.58152
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   0

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