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Structure of 29421-99-6
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4-Bromo-5-methylthiophene-2-carboxylic acid features a thiophene core functionalized with bromine at C4, a methyl group at C5, and a carboxylic acid at C2. This electron-deficient scaffold enables direct coupling in cross-coupling reactions, offering robust access to substituted heterocycles under standard conditions. The molecule exhibits enhanced stability and solubility in organic solvents, facilitating efficient integration into synthetic workflows.
4-Bromo-5-methylthiophene-2-carboxylic acid serves as a versatile building block in heterocyclic synthesis, enabling palladium-catalyzed cross-coupling reactions due to its bromo and carboxylic acid functionalities. The methylthiophene core provides orthogonal reactivity for further functionalization, while the carboxylic acid group facilitates derivatization or direct use in peptide coupling protocols. Bench-stable and readily purified by recrystallization, it supports scalable synthesis of bioactive thiophene scaffolds.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
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Lot numbers can be found on the outside label of a product: