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CS-W001157 4
Total: USD 88.00

2-Isopropylanisole

  • CAS No. 2944-47-0

  • Cat. No. CS-0154273
  • Purity≥98%
  • MDL No.MFCD00798590

*For research and further manufacturing use only, not for direct human use.

2-Isopropylanisole|CS-0154273

Structure of 2944-47-0

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General Information

  • CAS No. 2944-47-0
  • Cat. No. CS-0154273
  • Purity ≥98%
  • MDL No. MFCD00798590
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₁₄O
  • Molecular Weight 150.22
  • Synonym(s) 1-Isopropyl-2-methoxybenzene
  • SMILES CC(C)C1=CC=CC=C1OC

Description

2-Isopropylanisole features a para-methoxy group flanked by a sterically hindered isopropyl substituent, delivering enhanced stability and solubility in organic media. This combination enables efficient integration into complex aromatic scaffolds under standard reaction conditions.

Application

2-Isopropylanisole serves as a valuable aryl building block in synthetic organic chemistry, offering enhanced steric bulk and electronic modulation via its isopropyl and methoxy substituents. It functions reliably in electrophilic aromatic substitution and palladium-catalyzed coupling reactions, demonstrating good bench stability and ease of purification. Its defined regiochemistry enables predictable transformation pathways in the synthesis of pharmaceutical intermediates and functionalized aromatics.

Synthesis

  • Route1
    • null|null
      28000-93-3
    • ~67%
    • In-stock
      2-Isopropylanisole|CS-0154273
      2944-47-0

    References

    • Barcelo, Gerard; Grenouillat, Denis; Senet, Jean-Pierre; Sennyey, Gerard Tetrahedron, 1990 , vol. 46, # 6 p. 1839 - 1848
  • Route2
    • null|null
      420-26-8
    • null|null
      100-66-3
    • ~57%
    • In-stock
      2-Isopropylanisole|CS-0154273
      2944-47-0
    • 1-Isopropyl-3-methoxybenzene|CS-0454547
      6380-20-7
    • In-stock
      4-Isopropylanisole|CS-0154278
      4132-48-3

    References

    • Journal of the American Chemical Society, , vol. 106, # 18 p. 5284 - 5290
  • Route3
    • null|null
      75-29-6
    • null|null
      100-66-3
    • ~64%
    • In-stock
      2-Isopropylanisole|CS-0154273
      2944-47-0
    • 1-Isopropyl-3-methoxybenzene|CS-0454547
      6380-20-7
    • In-stock
      4-Isopropylanisole|CS-0154278
      4132-48-3

    References

    • Journal of the American Chemical Society, , vol. 106, # 18 p. 5284 - 5290

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   9.23
  • LogP   2.8186
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   2

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