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Structure of 29578-83-4
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1-Bromo-3-methoxy-5-methylbenzene features a bromine atom flanked by electron-donating methoxy and methyl groups, enhancing reactivity in palladium-catalyzed cross-coupling. The ortho-substitution pattern promotes regioselective transformations while maintaining bench-stable handling properties under standard conditions.
1-Bromo-3-methoxy-5-methylbenzene serves as a versatile aryl building block for palladium-catalyzed cross-coupling reactions, enabling efficient construction of biaryl and heteroaryl scaffolds. Its bromine functionality exhibits high reactivity in Suzuki, Stille, and Negishi couplings, while the methoxy and methyl groups provide orthogonal directing effects and enhanced solubility. The compound demonstrates excellent bench stability and facilitates straightforward purification, making it well-suited for iterative synthesis in medicinal chemistry and materials science applications.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: