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CS-W001157 4
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3-Bromo-6-(difluoromethyl)-2-ethoxypyridine

  • CAS No. 3008582-86-0

  • Cat. No. CS-0619902
  • Purity≥96%
  • MDL No.None
  • HazMat Fee +

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    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

3-Bromo-6-(difluoromethyl)-2-ethoxypyridine|CS-0619902

Structure of 3008582-86-0

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Description

3-Bromo-6-(difluoromethyl)-2-ethoxypyridine features a strategically positioned difluoromethyl group that enhances metabolic stability and modulates electronic properties. The bromine at C3 enables direct coupling in cross-coupling reactions, while the ethoxy substituent improves solubility and processability. This pyridine derivative serves as a key building block for bioactive molecules in medicinal chemistry and agrochemical development under standard conditions.

Application

3-Bromo-6-(difluoromethyl)-2-ethoxypyridine serves as a versatile building block in medicinal chemistry, enabling late-stage functionalization via palladium-catalyzed cross-coupling reactions. The bromo group facilitates efficient C–C and C–heteroatom bond formation, while the difluoromethyl and ethoxy substituents provide enhanced metabolic stability and tunable lipophilicity. This compound exhibits excellent bench stability and compatibility with standard synthetic workflows, making it well-suited for the construction of complex heterocyclic scaffolds in API development.

General Information

  • CAS No. 3008582-86-0
  • Cat. No. CS-0619902
  • Purity ≥96%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₈BrF₂NO
  • Molecular Weight 252.06
  • Synonym(s) None
  • SMILES BrC1=CC=C(N=C1OCC)C(F)F

Computational Chemistry Data

  • TPSA   22.12
  • LogP   3.1804
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   3

Safety Information

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GHS Pictogram : N/A
GHS No : N/A
Signal Word : N/A
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : N/A
Precautionary Statements : N/A

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