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Structure of 3013-27-2
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3-Fluoro-2-nitrotoluene features a fluorine atom at the meta position relative to a nitro group on a toluene scaffold, creating a highly electron-deficient aromatic system. This combination enables direct functionalization in cross-coupling reactions and serves as a key intermediate for pharmaceuticals and agrochemicals requiring orthogonal reactivity. The molecule exhibits enhanced stability under standard bench conditions and tolerates a range of reaction environments.
3-Fluoro-2-nitrotoluene serves as a versatile building block in synthetic organic chemistry, enabling direct functionalization at the aromatic ring due to the combined electron-withdrawing effects of the nitro and fluorine substituents. Its reactivity facilitates nucleophilic aromatic substitution and transition-metal-catalyzed coupling reactions, with the fluorine atom acting as a traceless directing group. The compound exhibits bench stability and is compatible with standard purification methods, making it well-suited for use in medicinal chemistry and process development workflows.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: