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CS-W001157 4
Total: USD 88.00

2,6-Dihydroxybenzoic acid

  • CAS No. 303-07-1

  • Cat. No. CS-0015783
  • Purity≥98%
  • MDL No.MFCD00002462

*For research and further manufacturing use only, not for direct human use.

2,6-Dihydroxybenzoic acid|CS-0015783

Structure of 303-07-1

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General Information

  • CAS No. 303-07-1
  • Cat. No. CS-0015783
  • Purity ≥98%
  • MDL No. MFCD00002462
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₆O₄
  • Molecular Weight 154.12
  • Synonym(s) None
  • SMILES O=C(O)C1=C(O)C=CC=C1O

Description

2,6-Dihydroxybenzoic acid features two hydroxyl groups positioned ortho to each other and para to the carboxylic acid, creating a rigid, electron-rich scaffold. This arrangement enhances intramolecular hydrogen bonding, improving solubility and thermal stability. The compound serves as a key building block in bioactive molecule synthesis, particularly for polyphenolic scaffolds and metal-chelating agents.

Application

2,6-Dihydroxybenzoic acid serves as a versatile building block for the synthesis of functionalized aromatic scaffolds and bioactive molecules. Its ortho-dihydroxy (catechol) motif enables metal chelation and oxidative coupling, while the carboxylic acid group facilitates direct amidation, esterification, or derivatization. The compound exhibits good bench stability and is compatible with standard purification methods, making it suitable for use in medicinal chemistry campaigns and materials science applications.

Synthesis

  • Route1
    • null|null
      108-46-3
    • ~%
    • 2,4-Dihydroxybenzoic acid Sodium aminosalicylate  Impurity|CS-0228943
      89-86-1
    • In-stock
      2,6-Dihydroxybenzoic acid|CS-0015783
      303-07-1

    References

    • Journal of the American Chemical Society, , vol. 62, p. 667
  • Route2
    • Salicylic acid, ≥99%|CS-1268363
      69-72-7
    • ~%
    • 2,4-Dihydroxybenzoic acid Sodium aminosalicylate  Impurity|CS-0228943
      89-86-1
    • In-stock
      Pyrocatechuic acid|CS-W019844
      303-38-8
    • 2,5-Dihydroxybenzoic acid Mesalazine  Impurity|CS-0229165
      490-79-9
    • In-stock
      2,6-Dihydroxybenzoic acid|CS-0015783
      303-07-1

    References

    • Archives of Toxicology, , vol. 68, # 7 p. 428 - 433
  • Route3
    • null|null
      108-46-3
    • ~%
    • In-stock
      2,6-Dihydroxybenzoic acid|CS-0015783
      303-07-1

    References

    • Organic Letters, , vol. 14, # 8 p. 1974 - 1977

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   77.76
  • LogP   0.796
  • H_Acceptors   3
  • H_Donors   3
  • Rotatable_Bonds   1

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