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Structure of 303144-44-7
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1-(pyrimidin-2-yl)piperidine-4-carboxylic acid features a pyrimidine ring linked to a piperidine scaffold bearing a carboxylic acid at the 4-position, enabling integration into bioactive molecules. This structure combines hydrogen-bonding capacity with moderate lipophilicity, facilitating interactions in target binding sites. The compound exhibits bench-stable handling characteristics and serves as a key intermediate in medicinal chemistry for kinase inhibitors and CNS-targeted therapeutics.
1-(Pyrimidin-2-yl)piperidine-4-carboxylic acid serves as a versatile building block for medicinal chemistry campaigns, enabling the construction of bioactive heterocyclic scaffolds. Its amide and carboxylic acid functionalities offer orthogonal reactivity for peptide coupling and derivatization, while the pyrimidine ring provides a robust hydrogen-bonding motif. The molecule exhibits excellent bench stability and facilitates purification via standard chromatographic methods, making it well-suited for high-throughput synthesis and lead optimization workflows.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H315-H319-H335
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Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501
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Lot numbers can be found on the outside label of a product: