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Structure of 30413-56-0
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4-Ethynyl-2-methylpyridine features a terminal alkyne group conjugated to an electron-deficient pyridine ring, enabling efficient copper-catalyzed azide-alkyne cycloaddition (CuAAC). The methyl substituent enhances solubility and modulates electronic properties, while the robust alkyne remains stable under standard bench conditions. This compound serves as a versatile building block for bioconjugation and materials synthesis.
4-Ethynyl-2-methylpyridine serves as a versatile building block in transition-metal-catalyzed coupling reactions, enabling efficient access to substituted pyridine scaffolds. Its terminal alkyne functionality facilitates Sonogashira and CuAAC transformations with high reliability, while the 2-methylpyridine core provides enhanced stability and orthogonal reactivity. The compound exhibits excellent bench stability and is readily purified by distillation or column chromatography, making it ideal for use in medicinal chemistry and materials synthesis workflows.
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GHS Pictogram :
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GHS No : GHS06
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Signal Word : Danger
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UN#: 2811
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Class : 6.1
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Packing Group : Ⅲ
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Hazard Statements : H301
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Precautionary Statements : P264-P270-P330-P405-P501
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Lot numbers can be found on the outside label of a product: