CRBN ligand-13

Name: CRBN ligand-13
Brand: ChemScene
Availability: InStock
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CAS No. 3050687-70-9
Cat. No. CS-1184960
Purity≥95%
MDL No.None

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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General Information

CAS No. 3050687-70-9
Cat. No. CS-1184960
Purity ≥95%
MDL No. None
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₁H₉BrClNO₂
Molecular Weight 302.55
Synonym(s) None
SMILES O=C(C(C1=CC=CC(Br)=C1Cl)CC2)NC2=O

Description

CRBN ligand-13 is a potent, bench-stable small molecule that selectively engages the CRL4^CRBN E3 ubiquitin ligase complex. This compound features a strategically positioned electron-deficient heterocycle enabling efficient recruitment of target proteins for ubiquitination and subsequent degradation via the proteasome pathway.

Application

CRBN ligand-13 serves as a well-defined molecular scaffold for targeted protein degradation studies, enabling selective recruitment of the E3 ubiquitin ligase complex. It functions as a high-affinity ligand for cereblon, facilitating efficient ubiquitination and subsequent proteasomal degradation of proximal target proteins. The compound exhibits robust bench stability, compatibility with diverse functional groups, and straightforward purification—making it a practical tool in chemical biology workflows and PROTAC development.

Safety Information

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GHS Pictogram : N/A	GHS No : N/A
Signal Word : N/A	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : N/A
Precautionary Statements : N/A

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Computational Chemistry Data

TPSA N/A
LogP N/A
H_Acceptors N/A
H_Donors N/A
Rotatable_Bonds N/A

Other Classifications

Building Blocks Functional Group Amide

Building Blocks Functional Group Bromide

Building Blocks Skeleton Aliphatic heterocycle compounds Piperidine compounds

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Key Words

CRBN ligand-13 sigmaCRBN ligand-13 manufacturerCRBN ligand-13 priceCRBN ligand-13 structureCRBN ligand-13 SDSbuy CRBN ligand-13CRBN ligand-13 supplierCRBN ligand-13 usesCRBN ligand-13 molecular weightprice of CRBN ligand-13CRBN ligand-13 chemical name formula of CRBN ligand-13

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CRBN ligand-13

CAS No. 3050687-70-9

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