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CS-W001157 4
Total: USD 88.00

N-Methylleucine

  • CAS No. 3060-46-6

  • Cat. No. CS-W008140
  • Molecule weight145.20
  • Purity≥95%
  • MDL No.MFCD00065919

*For research and further manufacturing use only, not for direct human use.

N-Methylleucine|CS-W008140

Structure of 3060-46-6

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General Information

  • CAS No. 3060-46-6
  • Cat. No. CS-W008140
  • Purity ≥95%
  • MDL No. MFCD00065919
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₁₅NO₂
  • Molecular Weight 145.20
  • Synonym(s) (S)-4-Methyl-2-(Methylamino)Pentanoic Acid;N-Methyl-L-leucine
  • SMILES CC(C[C@@](NC)([H])C(O)=O)C

Description

(S)-4-Methyl-2-(methylamino)pentanoic acid is a chiral α-amino acid derivative featuring a branched alkyl side chain and a methylamino group at the α-position. This configuration imparts enhanced metabolic stability and facilitates incorporation into peptidomimetic scaffolds. The molecule exhibits favorable solubility in aqueous and polar organic solvents, enabling seamless integration into synthetic workflows for bioactive peptide analogs and targeted drug discovery.

Application

(S)-4-Methyl-2-(methylamino)pentanoic acid serves as a chiral building block for peptidomimetics and bioactive heterocycles, offering well-established stereochemical control in synthetic routes. Its pendant α-amino acid framework enables efficient coupling reactions, while the methylamino group provides tunable basicity and metabolic stability. Bench-stable and amenable to standard purification methods, it functions reliably in solid-phase synthesis and medicinal chemistry campaigns.

Synthesis

  • Route1
    • null|null
      278175-37-4
    • ~%
    • In-stock
      N-Methylleucine|CS-W008140
      3060-46-6

    References

    • Journal of Organic Chemistry, , vol. 65, # 10 p. 3034 - 3041
  • Route2
    • null|null
      50-00-0
    • L-Leucine, 99%|CS-1269060
      61-90-5
    • ~85%
    • In-stock
      N-Methylleucine|CS-W008140
      3060-46-6

    References

    • da Silva, Renato A.; Estevam, Idalia H.S.; Bieber, Lothar W. Tetrahedron Letters, 2007 , vol. 48, # 43 p. 7680 - 7682
  • Route3
    • null|null
      212896-16-7
    • ~%
    • In-stock
      N-Methylleucine|CS-W008140
      3060-46-6

    References

    • Journal of Organic Chemistry, , vol. 65, # 10 p. 3034 - 3041

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   49.33
  • LogP   0.7051
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   4

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