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CS-W001157 4
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5-(Bromomethyl)picolinonitrile

  • CAS No. 308846-06-2

  • Cat. No. CS-0654805
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

5-(Bromomethyl)picolinonitrile|CS-0654805

Structure of 308846-06-2

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General Information

  • CAS No. 308846-06-2
  • Cat. No. CS-0654805
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₅BrN₂
  • Molecular Weight 197.03
  • Synonym(s) None
  • SMILES C1=CC(=NC=C1CBr)C#N

Description

5-(Bromomethyl)picolinonitrile features a bromomethyl group positioned ortho to the nitrile moiety on a pyridine ring, enabling selective functionalization in heterocyclic synthesis. This electron-deficient scaffold facilitates nucleophilic substitution reactions under mild conditions, offering efficient access to substituted pyridine derivatives with applications in medicinal chemistry and agrochemical development.

Application

5-(Bromomethyl)picolinonitrile serves as a versatile bifunctional building block in synthetic organic chemistry, enabling efficient construction of nitrogen-containing heterocycles and pharmaceutical intermediates. The bromomethyl group facilitates nucleophilic substitution reactions, while the picolinonitrile moiety provides a readily modifiable pyridine scaffold with enhanced electrophilicity at the 5-position. This compound exhibits excellent bench stability and compatibility with standard coupling protocols, facilitating straightforward purification and integration into multi-step syntheses.

Safety Information

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GHS Pictogram :
GHS No : GHS05
Signal Word : Danger
UN#: 3261
Class : 8
Packing Group : Ⅲ
Hazard Statements : H302+H312-H314
Precautionary Statements : P260-P264-P270-P280-P301+P330+P331-P302+P352-P304+P340-P330-P362+P364-P363-P405-P501

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Computational Chemistry Data

  • TPSA   36.68
  • LogP   1.84818
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   1

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