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CS-W001157 4
Total: USD 88.00

Boc-Glu-OBzl

  • CAS No. 30924-93-7

  • Cat. No. CS-W007875
  • Molecule weight337.37
  • Purity≥97%
  • MDL No.MFCD00065568

*For research and further manufacturing use only, not for direct human use.

Boc-Glu-OBzl|CS-W007875

Structure of 30924-93-7

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General Information

  • CAS No. 30924-93-7
  • Cat. No. CS-W007875
  • Purity ≥97%
  • MDL No. MFCD00065568
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₇H₂₃NO₆
  • Molecular Weight 337.37
  • Synonym(s) None
  • SMILES O=C(CC[C@H](NC(OC(C)(C)C)=O)C(OCC1=CC=CC=C1)=O)O

Description

Boc-Glu-OBzl (CAS 30924-93-7) facilitates γ-glutamyl peptide assembly via orthogonal Boc protection, enabling selective deprotection in solid-phase synthesis without side-chain interference.

Application

Boc-Glu-OBzl (CAS 30924-93-7) drives efficient peptide bond formation by serving as a stable, N-protected glutamic acid intermediate during chain elongation. It enables precise synthetic control. Researchers rely on its dual protection—Boc for the amine, benzyl ester for the carboxyl—to streamline coupling sequences. This setup minimizes side reactions and maximizes yield in both solution-phase and solid-phase synthesis. Its mild deprotection conditions support complex peptide assembly. The compound is vital in crafting pharmaceutical intermediates and bioconjugates. Scientists exploit its structural versatility to engineer functional materials like responsive hydrogels.

Synthesis

  • Route1

    References

    • Cantacuzene, D.; Pascal, F.; Guerreiro, C. Tetrahedron, 1987 , vol. 43, # 8 p. 1823 - 1826
  • Route2

    References

    • Sturtz; Appere; Breistol; Fodstad; Schwartsmann; Hendriks European Journal of Medicinal Chemistry, 1992 , vol. 27, # 8 p. 825 - 833
  • Route3
    • In-stock
      DL-Glutamic acid|CS-W022635
      617-65-2
    • null|null
      104-15-4
    • null|null
      501-53-1
    • ~%
    • In-stock
      Boc-Glu-OBzl|CS-W007875
      30924-93-7

    References

    • Chemical communications (Cambridge, England), , # 19 p. 1908 - 1909

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   101.93
  • LogP   2.4879
  • H_Acceptors   5
  • H_Donors   2
  • Rotatable_Bonds   7

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