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CS-W001157 4
Total: USD 88.00

3-Fluoropyridine-2-carbaldehyde

  • CAS No. 31224-43-8

  • Cat. No. CS-W001028
  • Purity≥97%
  • MDL No.MFCD07781234

*For research and further manufacturing use only, not for direct human use.

3-Fluoropyridine-2-carbaldehyde|CS-W001028

Structure of 31224-43-8

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General Information

  • CAS No. 31224-43-8
  • Cat. No. CS-W001028
  • Purity ≥97%
  • MDL No. MFCD07781234
  • Storage -20°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₄FNO
  • Molecular Weight None
  • Synonym(s) None
  • SMILES FC(C=CC=N1)=C1C=O

Description

3-Fluoropyridine-2-carbaldehyde features a fluorinated pyridine ring fused to an aldehyde functional group, enabling direct incorporation into heterocyclic scaffolds. This electron-deficient electrophile facilitates efficient coupling reactions and serves as a key building block in medicinal chemistry for targeted molecular design.

Application

3-Fluoropyridine-2-carbaldehyde serves as a versatile building block in medicinal chemistry, enabling direct incorporation of fluorinated heterocyclic motifs into target molecules. Its aldehyde functionality facilitates nucleophilic addition reactions, including reductive amination and Grignard additions, while the ortho-fluorine supports electrophilic substitution or directed metalation. The compound exhibits good bench stability and compatibility with standard purification methods, making it suitable for use in multi-step synthesis and API development workflows.

Synthesis

  • Route1
    • In-stock
      3-Fluoropyridine|CS-W011338
      372-47-4
    • null|null
      68-12-2
    • ~61%
    • In-stock
      3-Fluoropyridine-2-carbaldehyde|CS-W001028
      31224-43-8

    References

    • Bristol-Myers Squibb Company Patent: US2010/227894 A1, 2010 ; Location in patent: Page/Page column 55 ; US 20100227894 A1
  • Route2
    • In-stock
      3-Fluoropyridine|CS-W011338
      372-47-4
    • null|null
      60-29-7
    • ~%
    • In-stock
      3-Fluoropyridine-2-carbaldehyde|CS-W001028
      31224-43-8

    References

    • WO2012/177893 A2, ; Page/Page column 102-103 ; WO 2012/177893 A2
  • Route3
    • null|null
      68-12-2
    • ~11%
    • In-stock
      3-Fluoropyridine-2-carbaldehyde|CS-W001028
      31224-43-8

    References

    • MERCK and CO., INC. Patent: WO2007/81571 A2, 2007 ; Location in patent: Page/Page column 72 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   29.96
  • LogP   1.0332
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   1

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