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CS-W001157 4
Total: USD 88.00

2-(2-Chloroethoxy)acetonitrile

  • CAS No. 31250-08-5

  • Cat. No. CS-0158721
  • Purity≥98%
  • MDL No.MFCD19159867

*For research and further manufacturing use only, not for direct human use.

2-(2-Chloroethoxy)acetonitrile|CS-0158721

Structure of 31250-08-5

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General Information

  • CAS No. 31250-08-5
  • Cat. No. CS-0158721
  • Purity ≥98%
  • MDL No. MFCD19159867
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₄H₆ClNO
  • Molecular Weight 119.55
  • Synonym(s) None
  • SMILES N#CCOCCCl

Description

2-(2-Chloroethoxy)acetonitrile features a reactive chloroether functional group paired with a nitrile moiety, enabling efficient coupling in synthetic transformations. This bench-stable reagent integrates readily into nucleophilic substitution protocols and serves as a key intermediate in the construction of bioactive heterocycles and functionalized alkyl chains under standard conditions.

Application

2-(2-Chloroethoxy)acetonitrile serves as a versatile bifunctional building block in synthetic organic chemistry, enabling efficient construction of heterocyclic scaffolds and bioactive molecules. The nitrile group facilitates nucleophilic additions and subsequent transformations, while the chloroethyl ether moiety supports facile displacement reactions. Its bench-stable nature and compatibility with common reaction conditions make it ideal for iterative synthesis workflows and modular library development.

Synthesis

  • Route1
    • 1-Chloro-2-(chloromethoxy)ethane|CS-W013455
      1462-33-5
    • null|null
      71-43-2
    • ~%
    • In-stock
      2-(2-Chloroethoxy)acetonitrile|CS-0158721
      31250-08-5

    References

    • Salmi; Leimu; Kallio Suomen Kemistilehti B, 1944 , vol. 17, p. 18 Chem.Abstr., 1946 , p. 6491 Full Text Show Details Lingo; Henze Journal of the American Chemical Society, 1939 , vol. 61, p. 1575
  • Route2
    • 1-Chloro-2-(chloromethoxy)ethane|CS-W013455
      1462-33-5
    • ~%
    • In-stock
      2-(2-Chloroethoxy)acetonitrile|CS-0158721
      31250-08-5

    References

    • Salmi; Leimu; Kallio Suomen Kemistilehti B, 1944 , vol. 17, p. 18 Chem.Abstr., 1946 , p. 6491 Full Text Show Details Lingo; Henze Journal of the American Chemical Society, 1939 , vol. 61, p. 1575

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS06
Signal Word : Danger
UN#: 2810
Class : 6.1
Packing Group : Ⅲ
Hazard Statements : H301+H311+H331
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P361+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   33.02
  • LogP   0.76538
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   3

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