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Structure of 313468-63-2
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3-Chloroazetidine hydrochloride is a strained, electron-deficient heterocycle enabling direct functionalization in late-stage synthesis. This bench-stable crystalline solid features high reactivity at the azetidine ring due to angle strain and the chlorine substituent. It serves as a key building block for bioactive molecules, particularly in medicinal chemistry where its ability to integrate into complex scaffolds enhances target engagement.
3-Chloroazetidine hydrochloride serves as a versatile, bench-stable building block for the synthesis of bioactive heterocycles. Its strained four-membered ring enables efficient functionalization and facilitates rapid access to azetidinyl motifs prevalent in medicinal chemistry. The chloride group provides a reliable handle for nucleophilic substitution, enabling diversification via coupling reactions with amines, thiols, and other nucleophiles under mild conditions. This reagent functions effectively in standard synthetic workflows, offering high regioselectivity and compatibility with diverse protecting groups.
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GHS Pictogram :
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GHS No : GHS06
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Signal Word : Danger
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UN#: 2811
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Class : 6.1
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Packing Group : Ⅲ
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Hazard Statements : H301
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Precautionary Statements : P264-P270-P330-P405-P501
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Lot numbers can be found on the outside label of a product: