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CS-W001157 4
Total: USD 88.00

3-Chloroazetidine hydrochloride

  • CAS No. 313468-63-2

  • Cat. No. CS-0051403
  • Purity≥97%
  • MDL No.None
  • HazMat Fee +

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    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

3-Chloroazetidine hydrochloride|CS-0051403

Structure of 313468-63-2

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Description

3-Chloroazetidine hydrochloride is a strained, electron-deficient heterocycle enabling direct functionalization in late-stage synthesis. This bench-stable crystalline solid features high reactivity at the azetidine ring due to angle strain and the chlorine substituent. It serves as a key building block for bioactive molecules, particularly in medicinal chemistry where its ability to integrate into complex scaffolds enhances target engagement.

Application

3-Chloroazetidine hydrochloride serves as a versatile, bench-stable building block for the synthesis of bioactive heterocycles. Its strained four-membered ring enables efficient functionalization and facilitates rapid access to azetidinyl motifs prevalent in medicinal chemistry. The chloride group provides a reliable handle for nucleophilic substitution, enabling diversification via coupling reactions with amines, thiols, and other nucleophiles under mild conditions. This reagent functions effectively in standard synthetic workflows, offering high regioselectivity and compatibility with diverse protecting groups.

General Information

  • CAS No. 313468-63-2
  • Cat. No. CS-0051403
  • Purity ≥97%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₃H₇Cl₂N
  • Molecular Weight 128.00
  • Synonym(s) 3-Chloro-azetidine HCl
  • SMILES Cl.ClC1CNC1

Computational Chemistry Data

  • TPSA   12.03
  • LogP   0.6188
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   0

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS06
Signal Word : Danger
UN#: 2811
Class : 6.1
Packing Group :
Hazard Statements : H301
Precautionary Statements : P264-P270-P330-P405-P501

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