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CS-W001157 4
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1-Amino-2-methylindoline

  • CAS No. 31529-46-1

  • Cat. No. CS-0643163
  • Purity≥98%
  • MDL No.MFCD03840505

*For research and further manufacturing use only, not for direct human use.

1-Amino-2-methylindoline|CS-0643163

Structure of 31529-46-1

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General Information

  • CAS No. 31529-46-1
  • Cat. No. CS-0643163
  • Purity ≥98%
  • MDL No. MFCD03840505
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₁₂N₂
  • Molecular Weight 148.20
  • Synonym(s) None
  • SMILES NN1C2=C(CC1C)C=CC=C2

Description

The side-chain Mtt group can be selectively removed with 1% TFA in DCM [1,2,3] or DCM/HFIP/TFE/TES (6.5:2:1:0.5) [4], making this an excellent derivative for the synthesis by Fmoc SPPS of branched peptides, peptides modified at the lysine side-chain [5,6], for the construction of templates and multifunctionalized resins for combinatorial synthesis. Associated Protocols and Technical ArticlesCleavage and Deprotection Protocols for Fmoc SPPSLiterature references[1] K. Barlos, et al., C. H. Schneider & A. N. Eberle (Eds), ESCOM, Leiden, 1993, pp. 283. [2] A. Aletras, et al. (1995) Int. J. Peptide Protein Res., 45, 488. [3] L. Bourel, et al. (2000) J. Peptide Sci., 6, 264. [4] K. Barlos, personal communication. [5] P. Hoogerhout, et al. (1999) J. Peptide Res., 54, 436. [6] C. Park & K. Burgess (2001) J. Comb. Chem., 3, 257.

Safety Information

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Computational Chemistry Data

  • TPSA   29.26
  • LogP   1.3113
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   0

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