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Structure of 3159-04-4
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2-Chlorodibenzo[b,f][1,4]thiazepin-11(10H)-one features a rigid, polycyclic scaffold with a chlorine substituent at the 2-position, enhancing electron-withdrawing character and metabolic stability. This structure integrates well into bioactive molecule design, particularly for kinase inhibitors and CNS-targeted therapeutics. The lactam functionality supports hydrogen bonding interactions, while the fused aromatic system promotes planarity and π-stacking potential.
2-Chlorodibenzo[b,f][1,4]thiazepin-11(10H)-one serves as a versatile heterocyclic building block for medicinal chemistry campaigns, enabling direct functionalization at the C-2 position and facilitating downstream derivatization via nucleophilic substitution. Its rigid, planar structure enhances binding affinity in target-directed synthesis, while the thiazepinone core exhibits bench stability and compatibility with standard coupling reactions. The molecule functions effectively in the construction of complex scaffolds relevant to kinase inhibitors and CNS-targeted therapeutics.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: