1-Boc-2-Ethynylpyrrolidine

Name: 1-Boc-2-Ethynylpyrrolidine
Brand: ChemScene
Availability: InStock
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CAS No. 316141-37-4
Cat. No. CS-W006717
Purity≥97%
MDL No.None

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
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Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
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Structure of 316141-37-4

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General Information

CAS No. 316141-37-4
Cat. No. CS-W006717
Purity ≥97%
MDL No. None
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₁H₁₇NO₂
Molecular Weight 195.26
Synonym(s) tert-butyl 2-ethynylpyrrolidine-1-carboxylate
SMILES CC(C)(C)OC(=O)N1CCCC1C#C

Description

1-Boc-2-Ethynylpyrrolidine features a protected pyrrolidine core with a terminal alkyne handle, enabling direct incorporation into click chemistry workflows. The Boc group ensures stability and ease of handling, while the ethynyl moiety facilitates efficient copper-catalyzed azide-alkyne cycloaddition reactions under standard conditions.

Application

1-Boc-2-Ethynylpyrrolidine serves as a versatile building block for the synthesis of nitrogen-containing heterocycles and bioactive scaffolds. The terminal alkyne functionality enables reliable copper-catalyzed azide-alkyne cycloaddition (CuAAC), while the Boc-protected pyrrolidine offers excellent stability and compatibility with diverse reaction conditions. This reagent facilitates efficient access to triazole-linked compounds and is well-suited for iterative synthetic strategies in medicinal chemistry and process development.

Synthesis

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  316141-37-4
References
- Alcaide, Benito; Almendros, Pedro; Quiros, M. Teresa; Fernandez, Israel Beilstein Journal of Organic Chemistry, 2013 , vol. 9, p. 818 - 826

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

TPSA 29.54
LogP 2.0191
H_Acceptors 2
H_Donors 0
Rotatable_Bonds 0

Other Classifications

Building Blocks Skeleton Aliphatic heterocycle compounds Pyrrolidine compounds

Key Words

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1-Boc-2-Ethynylpyrrolidine

CAS No. 316141-37-4

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